Fri Sep 01 2023

27 articles - From Friday Aug 25 2023 to Friday Sep 01 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Inflamm Bowel Dis

Defining the Roles of Inflammatory Bowel Disease Clinical Pharmacists in the United States: A Systematic Review and National RAND/UCLA Consensus.

This consensus defines IBD clinical pharmacists' roles and provides a framework for embedded clinical pharmacists in IBD care.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Changes of trans and saturated fatty acid content in savoury baked goods from 2015 to 2021 and their effect on consumers' intake using substitution models; a study conducted in Greece.

Despite the reductions seen in i-TFA content of SBGs, food product reformulation efforts in Greece should focus not only on TFA content but also on SFA reduction to improve public health.

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Cross-sectional analysis of racial differences in hydration and neighborhood deprivation in young adults.

Our data suggest that compared with White young adults, Black young adults are hypohydrated and exhibit higher copeptin, and that greater neighborhood deprivation is associated with chronic underhydration irrespective of race. Clinical trial registry The data reported in this investigation were collected as part of a study registered on clinicaltrials.gov (NCT04576338)

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Genome-wide interaction analysis of folate for colorectal cancer risk.

Variation in 3p25.2 locus may modify the association of folate supplement with CRC risk. Experimental studies and studies incorporating other relevant -omics data are warranted to validate this finding.

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The associations of genetically predicted plasma alanine with coronary artery disease (CAD) and CAD risk factors: a Mendelian randomization study.

Alanine or factors affecting alanine may have causal effects on diabetes, blood glucose, lipid profiles and blood pressure, but not on CAD. Further studies are needed to clarify possible mechanisms.

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Inflamm Bowel Dis

CircASPH Enhances Exosomal STING to Facilitate M2 Macrophage Polarization in Colorectal Cancer.

Our study demonstrated that circASPH enhances exosomal STING to facilitate M2 macrophage polarization, which further accelerates CRC progression. The findings support circASPH as a promising therapeutic target for CRC treatment.

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Differentiation of Active Ulcerative Colitis vs Noninflammatory Bowel Disease Proctitis by Transperineal Superb Microvascular Imaging.

Transperineal ultrasonography with mSMI may enable the evaluation of rectal activity and differentiation of UC from non-IBD proctitis with accuracy comparable to endoscopy.

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Efficacy of Ustekinumab Optimization by 2 Initial Intravenous Doses in Adult Patients With Severe Crohn's Disease.

Optimization of ustekinumab by 2 initial intravenous inductions is more effective than standard therapy for adult patients with severe CD.

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Microbial and Metabolite Signatures of Stress Reactivity in Ulcerative Colitis Patients in Clinical Remission Predict Clinical Flare Risk.

High SR in UC is characterized by microbial signatures that predict clinical flare risk, suggesting that the microbiome may contribute to stress-induced UC flares.

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Nationwide Real-World Exclusive Enteral Nutrition Practice Over Time: Persistence of Use as Induction for Pediatric Crohn's Disease and Emerging Combination Strategy With Biologics.

Over the past 7.5 years, except during the COVID-19 pandemic, EEN usage rates have not changed despite an increase in biologic use, although combination induction is an emerging trend.

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Outcomes of a Comprehensive Specialist Inflammatory Bowel Disease Nursing Service.

A comprehensive IBD nursing service is associated with improved patient outcomes and quality of care, and reduced healthcare costs. This study supports the expanding role of IBD nurses in a modern multidisciplinary IBD service and the need for greater funding and integration of IBD nurses into IBD services.

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Relationship Between Rectal Swab and Tissue Samples in Mucosa-associated Microbiota in Patients With Inflammatory Bowel Disease.

Swab microbiota more closely resembled tissue microbiota relative to fecal microbiota, but there were still differences. Bowel preparation did not alter the overall swab microbiota in the short term but markedly changed the microbial composition in most patients.

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J Crohns Colitis

Alternative endoscopy reading paradigms determine score reliability and effect size in ulcerative colitis.

The ICC between the eMS of two trained and experienced central readers is unexpectedly low which reinforces that currently used central reading processes are still associated with several weaknesses.

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Efficacy and safety of approximately 3 years of continuous ozanimod in moderately to severely active ulcerative colitis: interim analysis of the True North open-label extension.

Among patients who achieved clinical response after 1 year of ozanimod treatment during True North, a high percentage sustained clinical and mucosal efficacy over 2 additional years in the OLE. No new safety signals were observed with long-term ozanimod use.

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Short Term Psychodynamic Psychotherapy in addition to standard medical therapy increases clinical remission in Adolescents and Young Adults with Inflammatory Bowel Disease: a randomised controlled trial.

An 8-week STPP intervention in addition to SMT effectively increases the steroid-free remission rates in AYA with quiescent IBD. Results do not support effects for other secondary outcomes.

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Superior predictive value of transmural over endoscopic severity for colectomy risk in ulcerative colitis: a multicenter prospective cohort study.

A superior predictive value was found for transmural versus endoscopic severity for colectomy risk in UC patients.

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Validation of the ACE (Albumin, CRP and Endoscopy) Index in Acute Colitis: Analysis of the CONSTRUCT dataset.

We have now reported and externally validated the ACE Index in Acute Colitis in a combined cohort of over 1000 patients from across the United Kingdom. The ACE Index may be used in conjunction with clinical judgement to help identify patients admitted with active UC who are at high risk of not responding to IV steroids. Further studies are required to improve objectivity and accuracy of assessment.

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Liver Transpl

Cost-effectiveness analysis of interventional liver-directed therapies for downstaging of hepatocellular carcinoma before liver transplant.

TARE is the more cost-effective downstaging strategy for patients with HCC exceeding Milan criteria when compared to TACE.

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Implementation of a national liver review board for exception requests in the united states: A two-year monitoring report.

Implementation of the NLRB improved efficiency, reduced case workloads, and standardized criteria for exception cases, with similar waitlist outcomes between patients with and without exception scores and improved equity in terms of access to liver transplant.

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Overcoming the hurdles of steatotic grafts in liver transplantation: insights into survival and prognostic factors.

Our study emphasizes the initial postoperative 30-day survival challenge in LT using fatty livers. However, with careful donor-recipient matching, e.g. avoiding use of steatotic donors with long cold ischemic time and high BSA ratios for recipients in the ICU, it is possible to enhance immediate GS, and in a longer time, outcomes comparable to those using non-fatty livers, DCD livers, or standard-risk older donors, can be anticipated. These novel insights into decision-making criteria for steatotic liver use provide invaluable guidance for clinicians.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Inflamm Bowel Dis

Therapeutic Drug Monitoring 2.0: Time to Assemble the Puzzle.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

1-Year Comparison of Clinical and Endoscopic Outcomes of Tofacitinib vs Vedolizumab for Ulcerative Colitis After Anti-Tumor Necrosis Factor Failure: A Real-World Cohort Study in the United States.

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All-or-Nothing Behavior and Catastrophic Thinking Predict Fatigue in Inflammatory Bowel Disease: A Prospective Cohort Study.

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J Crohns Colitis

6-mercaptopurine in ulcerative colitis: the potential of upfront dosing with allopurinol.

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Liver Transpl

Exploring the potential of ChatGPT in generating unknown clinical questions about liver transplantation: a feasibility study.

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Semaglutide is effective in achieving weight loss in liver transplant recipients.

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Small for size syndrome is the predominant form of early allograft dysfunction in living donor liver transplantation.

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Letters&Replies

Letters to the editors and authors’ replies